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Review Essays of Academic, Professional & Technical Books in the Humanities & Sciences


Internal Medicine

Goldman's Cecil Medicine: Expert Consult Premium Edition, 24th edition – Enhanced Online Features and Print, Single Volume (Goldman, Cecil Medicine: Text W/ Continually Updated Online) edited by Lee Goldman, MD and Andrew I. Schafer, MD (Elsevier Saunders)

This 24th Edition of Goldman's Cecil Medicine symbolizes a time of extraordinary advances in medicine and in technological innovations for the dissemination of information. This textbook and its associated electronic products incorporate the latest medical knowledge in formats that are designed to appeal to learners who prefer to access information in a variety of ways.

Since 1927, Goldman's Cecil Medicine in its many editions has been the world's most influential internal medicine reference. Edited by Lee Goldman, MD and Andrew I. Schafer, MD, with associate editors and contributors who number among the most recognized and respected authorities in the field, Cecil sets the standard for all other resources of its kind. This multi-media reference is the fastest and best place to find all of the authoritative, state-of-the-art clinical answers clinicians need. Definitive, unbiased, evidence-based guidance is at their fingertips in print and online, with regular updates by Goldman to ensure that the content is as current as the day it was published. Goldman's Cecil Medicine helps readers understand, diagnose, and treat any medical disorder they encounter in practice. Its focused coverage integrates the latest developments in biology with current evidence-based diagnosis and therapy – including medication doses. A masterfully organized format delivers fast access to the actionable information clinicians need.

Editor are Lee Goldman, MD, Dean of the Faculties of Health Sciences and Medicine, Executive Vice President for Health and Biomedical Sciences, Harold and Margaret Hatch Professor of the University, Professor of Medicine and of Epidemiology, Columbia University, New York; and Andrew I. Schafer, MD, Chairman, Department of Medicine, The E. Hugh Luckey Distinguished Professor of Medicine, Weill Cornell Medical College, Physician-in-Chief, New York-Presbyterian Hospital/Weill Cornell Medical Center, New York. New associate editors are Wendy Levinson, Donald W. Landry, Anil Rustgi, and W Michael Scheld, and returning associate editors are William P. Arend, James O. Armitage, David Clemmons, Jeffrey M. Drazen, and Robert C. Griggs. The massive volume contains 28 sections and 450 chapters.

With Goldman's Cecil Medicine clinicians are able to:

  • Stay on the cutting edge with updates personally selected by Goldman and regularly integrated directly into each chapter online.
  • SiSimplify and expedite decision making with templated chapters that include evidence-ranked references and algorithms to make clinically essential information leap off the page.
  • Access the fully searchable text anywhere, anytime. li>
  • Stay current with the latest knowledge and evidence-based practices. Comprehensive updates throughout include a brand-new chapter on "Applications of Molecular Technologies to Clinical Medicine," a completely revamped section on infectious diseases, and coverage of the latest cardiovascular techniques and treatments.
  • Be certain with expert, dependable, accurate answers from Goldman and an editorial team that is a veritable ‘who's who’ of modern medicine. Almost all contributors currently hold positions as Chairs of Internal Medicine departments around the U.S. and Canada and all are at the forefront of their respective subspecialty areas.
  • Reference information quickly thanks to a new, streamlined print format and easily searchable online access to supplemental figures, tables, algorithms, additional references, and expanded discussions as well as procedural videos, Seldom Asked Questions, and case studies.

The contents of Goldman's Cecil Medicine h have remained true to the tradition of a comprehensive textbook of medicine that carefully explains the why (the underlying normal physiology and pathophysiology of disease, now at the cellular and molecular as well as the organ level) and the how (now frequently based on Grade A evidence from randomized controlled trials). Descriptions of physiology and pathophysiology include the latest genetic advances in a practical format that strives to be useful to the nonexpert.

Medicine has entered an era when the acuity of illness and the limited time available to evaluate a patient have diminished the ability of physicians to satisfy their intellectual curiosity. As a result, the acquisition of information, quite easily achieved in this era, is confused with knowledge. Goldman and Schafer counteract this tendency with a textbook that not only informs but also stimulates new questions and gives a glimpse of the future path to new knowledge. Grade A evidence is specifically highlighted in the text and referenced at the end of each chapter. In addition to the information provided in the textbook, the Cecil website supplies expanded content and functionality. In many cases, the full articles referenced in each chapter can be accessed from the Cecil website.

The sections for each organ system begin with a chapter that summarizes an approach to patients with key symptoms, signs, or laboratory abnormalities associated with dysfunction of that organ system. Goldman's Cecil Medicine specifically provides clear, concise information regarding how a physician should approach more than 100 common symptoms, signs, and laboratory abnormalities, usually with a flow diagram, a table, or both for easy reference. In this way, Cecil remains a comprehensive text to guide diagnosis and therapy, not only for patients with suspected or known diseases but also for patients who may have undiagnosed abnormalities that require an initial evaluation.

In Goldman's Cecil Medicine all chapters are written by distinguished experts in each field. More successfully than other resources, Goldman's Cecil Medicine – the best internal medicine resource available since 1927 – far exceeds the competition in versatility, ease-of-use and up-to-datedness. This dynamic, multi-media reference – with its practical, straight-forward style, accessible organization, evidence-ranked references, and robust online content – is the fastest and best place to find authoritative, state-of-the-art clinical answers clinicians need. The volume provides definitive, unbiased, evidence-based guidance at one’s fingertips. The masterfully organized format delivers fast access to the actionable information clinicians need.

Harrison's Gastroenterology and Hepatology by Dan L. Longo and Anthony S. Fauci (McGraw-Hill Professional) Featuring the chapters on Gastroenterology and Hepatology that appear in the landmark Harrison's Principles of Internal Medicine, 17e, this compact clinical companion delivers all the latest knowledge in the field, backed by the scientific rigor and reliability that has defined Harrison's.

You'll find coverage that reflects the expertise of renowned editors and contributors -- presented in a carry-anywhere format that makes it ideal for the classroom, the wards, or the point of care. With its ease of use, indispensable diagnosis-speeding guidelines, and acclaimed state-of-the-art strategies, Harrison's Gastroenterology and Hepatology is a must for students and clinicians alike.

Harrison's Gastroenterology and Hepatology delivers:

  • Complete coverage of need-to-know gastroenterology and hepatology topics, including cardinal manifestations of disease, differential diagnosis and diagnostic evaluation, management of diseases and disorders, and obesity, nutrition, and eating disorders
  • References updated since the publication of HPIM 17e
  • Content from the acclaimed Harrison's DVD in print form, including a complete atlas of liver disease
  • 58 chapters written by physicians who have made seminal contributions to the body of knowledge in their areas of expertise
  • Integration of pathophysiology with clinical management topics in each of the disease-oriented chapters
  • 140 high-yield questions and answers drawn from Harrison's Principles of Internal Medicine Self-Assessment and Board Review, 17e
  • Helpful appendix of laboratory values of clinical importance

Everything you would expect from Harrison's tailored to your specialty
Cardinal Manifestations of Gastrointestinal Disease; Evaluation of the Patient with Alimentary Tract Symptoms; Disorders of the Alimentary Tract; Infections of the Alimentary Tract; Evaluation of the Patient with Liver Disease; Disorders of the Liver and Biliary Tree; Liver Transplantation.

Harrison's Nephrology and Acid-Base Disorders by J. Jameson and Joseph Loscalzo (McGraw-Hill Professional) Featuring the chapters on Nephrology and Acid-Base Disorders that appear in the landmark Harrison's Principles of Internal Medicine, 17e, this compact clinical companion delivers all the latest knowledge in the field, backed by the scientific rigor and reliability that have defined Harrison's.

You'll find coverage that reflects the expertise of renowned editors and contributors -- presented in a carry-anywhere format that makes it ideal for the classroom, the wards, or the point of care. With its ease of use, indispensable diagnosis-speeding guidelines, and acclaimed state-of-the-art strategies, Harrison's Nephrology and Acid Base Disorders is a must for students and clinicians alike.

Harrison's Nephrology and Acid-Base Disorders delivers:

  • Current, complete coverage of all major renal-related presentations and diseases, as well as acid-base and electrolyte disorders
  • 63 high-yield self-assessment Q&A for exam and board review drawn from Harrison's Principles of Internal Medicine Self-Assessment and Board Review, 17e
  • A timely focus on the impact of scientific advances, with a look at how genetics and molecular biology are transforming the field
  • New diagnostic and treatment strategies based on evidence from recent clinical studies
  • Integration of pathophysiology with clinical management topics in each of the disease-oriented chapters
  • Valuable content in print form from the acclaimed Harrison's DVD
  • Helpful appendix that highlights laboratory values of clinical importance

Everything you would expect from Harrison's tailored to your specialty
Introduction to the Renal System; Alterations of Renal Function and Electrolytes; Acute and Chronic Renal Failure; Glomerular and Tubular Disorders; Renal Vascular Disease; Urinary Tract Infections and Obstruction; Cancer of the Kidney and Urinary Tract; Appendix: Laboratory Values of Clinical Importance; Review and Self-Assessment

The Harrison’s specialty series is written by the same world-renowned author team who brought you Harrison’s Principles of Internal Medicine, 17e:
Anthony S. Fauci, MD; Eugene Braunwald, MD; Dennis L. Kasper, MD; Stephen L. Hauser, MD; Dan L. Longo, MD; J. Larry Jameson, MD, PhD; Joseph Loscalzo, MD, PhD 

Harrison's Principles of Internal Medicine 17th Edition edited by Dennis L. Kasper et al (McGraw-Hill Professional) This behemoth standard textbook and reference work of Internal medicine is written with such comprehensiveness and reasonable clarity that lay people can consult it with profit when needing to research diagnosis and to discover treatment modalities for their condition. The 17th Edition improves on a winning formula with:

State-of-the-art coverage of over 4,700 diseases and disorders—more than any other internal medicine text – in the areas of oncology and hematology; infectious diseases; cardiology; pulmonology; gastroenterology; clinical immunology; rheumatology; endocrinology; and neurology.

A brand new full color format—665 full color drawings, 175 clinical and laboratory images, and hundreds of boxes, tables, and algorithms that use color to guide you to the information you need ASAP in everyday patient care
Thorough revision and updates of virtually all chapters

The addition of key new chapters – including extensive new coverage of Critical Care Medicine.

145 algorithms for making accurate clinical decisions fast at the point of care.

1,160 easy-access tables for immediate access to vital information and formulas.

Cardinal manifestations of disease/signs and symptoms in 55 chapters (you’ll find yourself turning to this section over and over again). Here you will find all the major manifestations, such as fever, pain, aches and rash, presented in depth, with a referral that takes you to the disease section for the complete chapter.

Excerpt: The first edition of Harrison's Principles of Internal Medicine was published more than half a century ago. Over the decades, this text-book has evolved to reflect the continuing advances in the field of internal medicine and to meet the growing information base required of medical students and clinical practitioners. The users of this six­teenth edition of Harrison's will not even have to open the volume to see that it marks a transition point in the book's history. The new cover is only the most obvious indication of a new direction for Harrison's.

In shaping and revising this new version, the Editors have com­mitted themselves to making the textbook as useful as possible to students and practitioners coping with the demands of modern medicine. The growth of evidence-based medicine, the prominence of man-aged care, and the explosion of information in fundamental areas such as the genetics of disease are only three of the many factors that make these demands different from those faced by physicians only a decade ago. Just as the cover retains key elements of the classic book, the content of the sixteenth edition retains the essential facts that remain clinically useful and important. However, through modifications in both its format and its content, the new Harrison's addresses the changing needs of its readers.

The sixteenth edition of Harrison's has a full-color format that facilitates quick reference and allows the inclusion of hundreds more high-quality illustrations than in previous editions. We expect that the reader's convenience will be well served by the placement of color illustrations within the chapters rather than in the separate color atlas used in earlier editions. While providing the basic-science information that is critical to an understanding of biology and pathophysiology, this edition focuses more directly and extensively than ever on crucial aspects of clinical practice. Areas of emphasis include the approach to the patient, differential diagnosis, state-of-the-art treatment options, and disease prevention. Key topics, such as the immune system and HIV infection/AIDS, are covered in chapters amounting to "mini-text­books." New sections offer information on the formidable challenges posed by critical care medicine and by the threat of bioterrorism. New chapters provide coverage of highly relevant clinical topics such as disease screening, perimenopausal management and hormone replacement therapy, and end-of-life care. Virtually every chapter in this edi­tion has been substantially rewritten, and 46 chapters either are entirely new or have new authors.

These are only highlights of the changes that the Editors hope will make the new Harrison's a helpful tool—not only for the student who needs an expert source of basic knowledge in internal medicine, but Also for the pressured practitioner who needs a clear, concise, and lanced distillation of the best information on which to base daily clinical decisions.

Part One, "Introduction to Clinical Medicine," contains a new chapter that provides practical information about the screening ap­proaches that every internist should consider for routine health main-Alliance. This chapter discusses the principles and guidelines used in screening for common conditions such as cancer, hypertension, lipid disorders, and osteoporosis. Another new chapter offers a pragmatic approach to the medical evaluation of patients who are about to un­dergo surgical procedures. In light of the growth of the hospice movement and the increased awareness of the sensitive issues—physical, mental, social, and existential—that surround end-of-life care, a new chapter on this complex topic provides insights, information, and guid­ance to practitioners dealing with dying patients and their families. The chapter on women's health has been entirely revised and offers a broad overview of the approach to disorders that affect women disproportionately.

Part Two, "Cardinal Manifestations and Presentation of Diseases,"serves as a comprehensive introduction to clinical medicine as well as a practical guide to the care of patients with these manifestations. Each section focuses on a particular group of disorders, examining the con­cepts of pathophysiology and differential diagnosis that must be con­sidered in caring for patients with these common clinical presentations. Major symptoms are reviewed and correlated with specific disease states, and clinical approaches to patients presenting with these symp­toms are summarized. Every chapter has been updated, and three chap­ters have new authors. The chapter on sexual dysfunction now ad-dresses disorders in both men and women.

Given the rapid advances in human genetics over the past several years, Part Three, "Genetics and Disease," has once again been com­pletely updated. The material included in this edition is strongly geared toward clinical practice, in which genetic information increasingly comes into play. The new chapter on stem cell and gene transfer in clinical medicine addresses a timely and controversial topic, defining different types of stem cells and discussing their potential clinical ap­plications.

Part Four, "Nutrition," covers nutritional considerations related to clinical medicine. Areas of focus include nutritional and dietary as­sessment, nutritional requirements, protein-energy malnutrition, eating disorders, obesity, and enteral and parenteral nutrition therapy.

The core of Harrison's continues to encompass the disorders of the organ systems and is contained in Parts Five through Sixteen. These sections include succinct accounts of the pathophysiology of diseases involving the major organ systems as well as infectious diseases, with an emphasis on clinical manifestations, diagnostic proce­dures, differential diagnosis, and treatment strategies and guidelines.

Part Five, "Oncology and Hematology," includes four chapters by new authors. An increasing proportion of patients who develop cancer are being cured. It is important to detect late consequences as early as possible in their natural history to optimize outcome. The chapter on the late consequences of cancer and its treatment helps physicians following such patients to know what to look for in addition to a recurrence of the cancer. Advances in the management of many cancers are highlighted—for example, the dramatic impact of imatinib mesylate (Gleevec) on chronic myeloid leukemia and gastrointestinal stromal cell tumors and the role of rituximab in the management of lymphoma and autoimmune diseases. The chapter delineating the prin­ciples of radiation therapy has been entirely rewritten by Eli Glatstein and is a companion piece to this author's chapter on radiation bioterrorism in Part Seven (see below). The hematology section features the World Health Organization's new classification of lymphoid and my­eloid neoplasms. One of the most rapidly expanding areas of medicine is the development of novel agents to interfere with blood coagulation. With a new author who is an expert in this field, the chapter on anti-coagulant, fibrinolytic, and antiplatelet therapy reviews all these new products and their indications.

Part Six, "Infectious Diseases," summarizes the latest information on pathology, genetics, and epidemiology while focusing sharply on the needs of clinicians who must accurately diagnose and treat infec­tions under time pressure and cost constraints. In particular, the inclu­sion of dozens more illustrations in full color provides easily acces­sible information to assist clinicians with these challenges. Specific recommendations are provided for therapeutic regimens, including the drug of choice, dose, duration, and alternatives. Current trends in an­timicrobial resistance are presented and considered in light of their impact on therapeutic choices. A new chapter offers key information on the management of the complex clinical issues raised by Clostrid­ium difficile–associated disease, including pseudomembranous colitis. New authors cover the latest advances in the management of diseases

caused by staphylococci and nontuberculous mycobacteria, viral gas­troenteritis, and brucellosis. The superb chapter by Raphael Dolin on common viral respiratory infections has been expanded to include thorough coverage of severe acute respiratory syndrome (SARS). Now placed in a separate section with the overview of the human retrovi­ruses, the chapter on HIV infection and AIDS by Anthony S. Fauci and H. Clifford Lane has been completely revised and updated, with an emphasis on therapeutic strategies. This chapter is widely consid­ered to be a classic in the field; its clinically pragmatic focus in combination with its comprehensive and analytical approach to the patho­genesis of HIV disease has allowed its use as the sole complete reference on HIV/AIDS in medical schools.

In recent years, physicians have found themselves on the front line of response to bioterrorist attacks around the world. Since the attacks on the United States on September 11, 2001, and the subsequent an­thrax attacks, the nation has been preparing for the further attacks that will inevitably come. Part Seven, "Bioterrorism and Clinical Medicine," consists of entirely new material written by authorities in three areas of bioterrorism: microbial, chemical, and radiation. Edited by Harrison's editor Anthony S. Fauci, these chapters are written suc­cinctly and include easily readable charts, tables, and algorithms; their goal is to confer an understanding of the pathogenesis, diagnosis, treatments, and prognosis of the diseases in question.

Part Eight, "Disorders of the Cardiovascular System," is once again edited by the preeminent expert in the field, Eugene Braunwald. A new chapter covers the clinically important topics of unstable angina and non-ST-segment elevation myocardial infarction; three other chap­ters have new authors; and every chapter has been revised to reflect the latest trends and strategies for management. These include primary percutaneous coronary intervention for ST-segment elevation myo­cardial infarction as well as new drugs and devices for the treatment of heart failure.

Enormous strides have been made in the use of lung transplantation for selected patients with end-stage, irreversible, pulmonary parenchy­mal and vascular disease. Part Nine, "Disorders of the Respiratory System," includes a chapter by a new author that focuses on the selection of patients for this intervention. New authors have also taken on the broad topic of pneumonia and lung abscess, providing focus and a clinical perspective to help the reader grasp the central issues involved in the diagnosis and management of both community-ac­quired and nosocomial disease.

With advances in health care delivery and pressures aimed at cost containment, critical care units account for a growing percentage of hospital beds. Part Ten, "Critical Care Medicine," is a new section of Harrison's that is devoted to the provision of optimal care in this medical setting of growing importance. Incorporating both new chap­ters and refocused chapters on topics covered in previous editions, this part deals with three main areas: respiratory critical care, shock and cardiac arrest, and neurologic critical care. The approach to the patient and the central tenets underlying critical care are at the heart of this part of the sixteenth edition.

Part Eleven, "Disorders of the Kidney and Urinary Tract," includes contributions from several new authors and, as in previous editions, provides a thorough overview of the urinary-tract disorders encoun­tered in internal medicine.

Part Twelve, "Disorders of the Gastrointestinal System," includes a new chapter on familial Mediterranean fever. The chapter on the approach to the patient with gastrointestinal disease has been com­pletely reworked by a new author, as has the chapter on diverticular and vascular disease of the bowel. The chapters on the various cate­gories of viral hepatitis have been extensively revised and updated to reflect breakthrough advances in treatment.

The first chapter in Part Thirteen, "Disorders of the Immune System, Connective Tissue, and Joints," provides an introduction to the immune system that has become a classic in its field and is often used as the textbook of immunology in postgraduate and medical schoolcourses. This chapter combines an in-depth description and analysis of the principles of basic immunology with an easy flow into the ap­plication of these principles to clinical disease states. Its description of the relationship of innate to adaptive immunity is a model for un­derstanding the intricacies of the human immune system. Once again, the authors have extensively revised this chapter to bring it up to date with regard to recent rapid advances in both basic and clinical im­munology. In the section on disorders of immune-mediated injury, the spondyloarthropathies have been grouped together in one chapter that clearly and comprehensively discusses the similarities and dissimilar­ities among the various diseases in this category. The breakthrough advances in immunomodulatory therapy that have been realized in rheumatology over the past few years are captured in the spondyloarthropathy chapters and in the extensively revised chapters on rheu­matoid arthritis and systemic lupus erythematosus. A new chapter covers fibromyalgia, arthritis associated with systemic disease, and other arthritides.

Part Fourteen, "Endocrinology and Metabolism," includes six chapters with new authors as well as a timely new chapter on the perimenopause transition and hormone replacement therapy. The writ­ing of the latter chapter coincided with publication of results from the Women's Health Initiative that unexpectedly showed an increased risk of cardiovascular disease among women who received estrogen treatments. The author reviews the literature in this area and provides prac­tical algorithms for the management of patients during this transition. The new authors of the chapter on disorders of sexual differentiation highlight novel insights derived from elucidation of the genetic basis of sex determination. The outstanding new review of bone and mineral metabolism lays a superb foundation for an understanding of the path­ophysiology and treatment of various metabolic bone diseases. The newly authored version of the chapter on disorders of lipoprotein me­tabolism offers a much sharper focus on the classification, diagnosis, and treatment of disorders of cholesterol and triglyceride metabolism, emphasizing the use of statins for the reduction of cardiovascular risk. The new chapter on Wilson disease reports on the substantially mod­ified treatment recommendations for this entity.

Part Fifteen, "Neurologic Disorders," has been extensively up-dated. A comprehensive new chapter on Alzheimer's disease and re­lated dementias summarizes the recent explosion of knowledge on this topic, highlighting the new understanding of the genetics of these de­mentias and the molecules that trigger them as well as providing a clinical guide to diagnosis, differential diagnosis, and the latest treat­ments. The new chapter on Parkinson's disease reviews the recent genetic findings and provides an authoritative approach to therapy, including surgical options. The chapter on cerebrovascular diseases has been extensively rewritten, offering an evidence-based approach to the treatment and prevention of stroke, the third leading killer in the Western world. The updated chapter on multiple sclerosis presents the most recent advances in therapy and a practical approach to management of different stages of the disease. Finally, the recognition of bovine spongiform encephalopathy in many regions of the world has focused the global health care community on the biology and clinical manifestations of prion diseases; the sixteenth edition of Harrison's includes a comprehensive review of this subject by Nobel Laureate Stanley Prusiner.

Part Sixteen, "Poisoning, Drug Overdose, and Envenomation," has been thoroughly revised and streamlined to focus on the topics most relevant to internal medicine.

In view of the requirements for continuing education for licensure and relicensure as well as the emphasis on certification and recertifi­cation, a revision of the PreTest Self-Assessment and Review will again be published with this edition. This volume is in the capable hands of a new author, Dr. Charles Wiener from Johns Hopkins. It consists of several hundred questions based on the sixteenth edition of Harrison's, along with answers and explanations for the answers. The Companion Handbook, which was pioneered as a supplement to the eleventh edition of Harrison's, has been reworked as a concise quick-reference clinical manual; the Manual of Medicine will appear

shortly after the publication of this edition, along with a PDA version, Harrison's OnHand. In 1998, Harrison's went online to provide a "living" textbook of internal medicine. In addition to permitting full search capabilities of the text, Harrison's Online offers frequent up-dates, reports of clinical trials, practice guidelines, online lectures, and concise reviews of timely topics as well as additional and updated references (with links to MEDLINE abstracts) and illustrations.

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Harrison's Principles of Internal Medicine 17th Edition edited by Dennis L. Kasper et al (McGraw-Hill Professional) This behemoth standard textbook and reference work of Internal medicine is written with such comprehensiveness and reasonable clarity that lay people can consult it with profit when needing to research diagnosis and to discover treatment modalities for their condition.